1) Penicillin was taken into consideration a "miracle drug" for all of the following reasons EXCEPT

A) it was the first antibiotic.

You are watching: Which of the following organisms would most likely be sensitive to natural penicillin?

B) that does not affect eukaryotic cells.

C) that inhibits gram-positive cell wall synthesis.

D) it has actually selective toxicity.

E) it kills bacteria.


2) A medicine that inhibits mitosis, such together griseofulvin, would certainly be more effective against

A) gram-positive bacteria.

B) gram-negative bacteria.

C) fungi.

D) wall-less bacteria.

E) mycobacteria.


3) most of the accessible antimicrobial agents are effective against

A) viruses.

B) bacteria.

C) fungi.

D) protozoa.

E) every one of the answers space correct.


4) Antimicrobial peptides (AMPs) typically work by

A) inhibiting protein synthesis.

B) disrupting the plasma membrane.

C) complementary base pairing through DNA.

D) inhibiting cell-wall synthesis.

E) hydrolyzing peptidoglycan.


5) In what method are semisynthetic penicillins and also natural penicillins alike?

A) Both are broad spectrum.

B) Both room resistant come penicillinase.

C) Both are resistant to stomach acids.

D) Both are bactericidal.

E) Both are based upon β-lactam.


6) i beg your pardon of the complying with antibiotics is not bactericidal?

A) aminoglycosides

B) cephalosporins

C) polyenes

D) rifampins

E) penicillin


7) Which one of the complying with does no belong v the others?

A) bacitracin

B) cephalosporin

C) monobactam

D) penicillin

E) streptomycin


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The antibiotic tetracycline binds to the 30S subunit of the ribosome, as displayed by the dark black bar ~ above the right portion of the diagram in figure 20.1. The effect is to

A) protect against attachment the DNA.

B) avoid peptide shortcut formation.

C) avoid transcription.

D) prevent the ribosom from relocating along the mRNA.

E) interfere through the attachment of the tRNA to mRNA-ribosome complex.


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The antibiotic chloramphenicol binds to the 50S subunit that the ribosome, as displayed in number 20.2. The result is to

A) avoid mRNA-ribosome binding in eukaryotes.

B) prevent peptide bond development in prokaryotes.

C) prevent polypeptide elongation in eukaryotes.

D) prevent transcription in prokaryotes.

E) stop ribosome formation in bacteria.


10) i beg your pardon of the following antimicrobial agents has the fewest next effects?

A) streptomycin

B) tetracycline

C) penicillin

D) erythromycin

E) chloramphenicol


11) i beg your pardon of the following drugs does no act by compete inhibition?

A) ethambutol

B) isoniazid

C) streptomycin

D) sulfonamide

E) trimethoprim


12) which of the adhering to methods of action would it is in bacteriostatic?

A) competitive inhibition with folic mountain synthesis

B) inhibition the protein synthesis

C) injury to plasma membrane

D) inhibition that cell wall synthesis

E) compete inhibition with DNA gyrase


13) i beg your pardon of the complying with antibiotics is recommended for use against gram-negative bacteria?

A) polyenes

B) bacitracin

C) cephalosporin

D) penicillin

E) polymyxin


14) which of the following antimicrobial agents is recommended because that use versus fungal infections?

A) amphotericin B

B) bacitracin

C) cephalosporin

D) penicillin

E) polymyxin


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15) 5) In Table 20.1, as portrayed by the data shown, the minimal bactericidal concentration the antibiotic X is

A) 2 μg/ml.

B) 10 μg/ml.

C) 15 μg/ml.

D) 25 μg/ml.

E) The answer can not be determined based on the info provided.


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16) In Table 20.1, the minimal inhibitory concentration that antibiotic X is

A) 2 μg/ml.

B) 10 μg/ml.

C) 15 μg/ml.

D) 25 μg/ml.

E) The answer cannot be determined based upon the info provided.


17) much more than half of ours antibiotics are

A) produced by fungi.

B) created by bacteria.

C) synthesized in laboratories.

D) developed by Fleming.

E) created by eukaryotic bio organisms.


18) to date, most of our herbal antibiotics have actually been found to be developed by members the what genus?

A) Streptomyces

B) Bacillus

C) Penicillium

D) Paenibacillus

E) Cephalosporium


19) which of the following is mismatched?

A) Ehrlich — "magic bullet" theory

B) Fleming — initial identification of penicillin"s effect on gram-positive microbial growth

C) Florey and Chain — to know of Penicillium as the producer of penicillin

D) Kirby and also Bauer — disc-diffusion method

E) nobody of this is mismatched.


20) which compound would be the most valuable to treat candidiasis?

A) uracil

B) thymine

C) flucytosine

D) guanine

E) penicillin


21) i m sorry of the complying with antibiotics are used to treat fungal infections?

aminoglycosides

cephalosporins

griseofulvin

polyenes

bacitracin

A) 1, 2, and also 3

B) 3 and 4

C) 3, 4, and 5

D) 4 and also 5

E) all of these antibiotics are provided to act fungal infections.


22) i m sorry of the adhering to antibiotics does no interfere v cell wall surface synthesis?

A) cephalosporins

B) macrolides

C) herbal penicillins

D) semisynthetic penicillins

E) vancomycin


23) The antimicrobial drugs with the broadest spectrum of task are

A) aminoglycosides.

B) chloramphenicol.

C) penicillin G.

D) macrolides.

E) tetracyclines.


24) which of the complying with statements is FALSE?

A) Fluoroquinolone inhibits DNA synthesis.

B) Acyclovir inhibits DNA synthesis.

C) Amantadine inhibits the relax of viral main point acid.

D) Interferon inhibits glycolysis.

E) Azoles inhibit plasma membrane synthesis.


25) Protozoan and helminthic conditions are difficult to treat because

A) your cells room structurally and functionally comparable to human being cells.

B) they replicate inside human being cells.

C) they execute not have ribosomes.

D) they carry out not reproduce.

E) they have more genes 보다 bacteria.


26) i m sorry of the following organisms would certainly MOST likely be sensitive to organic penicillin?

A) helminths

B) Streptococcus pyogenes

C) penicillinase-producing Neisseria gonorrhoeae

D) Penicillium

E) Mycoplasma


27) which of the adhering to statements around drug resistance is FALSE?

A) It may be carried on a plasmid.

B) It might be transferred from one bacter to one more during conjugation.

C) It may be because of enzymes the degrade part antibiotics.

D) it is uncovered only in gram-negative bacteria.

E) It might be because of increased uptake of a drug.


28) i m sorry of the complying with does not constitute an advantage of using two antibiotics together?

A) It deserve to prevent drug resistance.

B) it lessens the toxicity of individual drugs.

C) two are constantly twice as reliable as one.

D) It enables treatment to be provided prior come diagnosis.

E) every one of these are benefits of using 2 antibiotics together.


29) medicine resistance occurs

A) since bacteria room normal microbiota.

B) when antibiotics are offered indiscriminately.

C) against antibiotics and not versus synthetic chemotherapeutic agents.

D) as soon as antibiotics are taken after the symptom disappear.

E) every one of the answers space correct.


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30) In Table 20.2, the most effective antibiotic tested was

A) A.

B) B.

C) C.

D) D.

E) The answer cannot be determined based upon the details provided.


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31) In Table 20.2, the antibiotic that displayed bactericidal action was

A) A.

B) B.

C) C.

D) D.

E) The answer cannot be determined based upon the info provided.


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32) In Table 20.2, which antibiotic would certainly be most useful for treating a Salmonella infection?

A) A

B) B

C) C

D) D

E) The answer can not be determined based upon the info provided.


33) which of the adhering to would it is in selective against the tubercle bacillus?

A) bacitracin — inhibits peptidoglycan synthesis

B) ethambutol — inhibits mycolic mountain synthesis

C) streptogramin — inhibits protein synthesis

D) streptomycin — inhibits protein synthesis

E) vancomycin — inhibits peptidoglycan synthesis


34) In the existence of penicillin, a cell dies because

A) it lacks a cell wall.

B) it plasmolyzes.

C) it undergoes lysis.

D) it lacks a cell membrane.

E) its components leak out.


35) Lamisil is an allylamine provided to treat dermatomycoses. Lamisil"s an approach of action is similar to the of

A) polymyxin B.

B) azole antibiotics.

C) echinocandins.

D) griseofulvin.

E) bacitracin.


36) Niclosamide stays clear of ATP generation in mitochondria. Girlfriend would intend this medicine to be efficient against

A) gram-negative bacteria.

B) gram-positive bacteria.

C) helminths.

D) Mycobacterium tuberculosis.

E) viruses.


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The data in Table 20.3 display that these bacteria

A) are pathogenic.

B) emerged resistance come antibiotics.

C) were eliminated by 0.125 μg/ml of antibiotic X.

D) were killed by 0.5 μg/ml that antibiotic X.

E) were resistant to 1.0 μg/ml in ~ the start of the experiment.


38) i m sorry of the adhering to statements about drugs the competitively inhibit DNA polymerase or RNA polymerase is FALSE?

A) They have the right to potentially cause mutations.

B) They room used against viral infections.

C) castle can influence host cell DNA synthesis.

D) They cause cellular plasmolysis.

E) castle interfere with protein synthesis.


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The substrate for transpeptidase supplied to synthesize peptidoglycan is shown in number 20.3. I m sorry of the drugs presented would inhibit peptidoglycan synthesis?

A) a B) b C) c D) d E) e
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The structures of the influenza drug Tamiflu and sialic acid, the substrate for influenza virus"s neuramidase, are displayed in number 20.4. What is the technique of action of Tamiflu?

A) inhibits cell wall surface synthesis

B) inhibits plasma membrane synthesis

C) inhibits synthetic of neuramidase

D) compete inhibition

E) prevents synthesis of virus spikes


41) which of the complying with does NOT influence eukaryotic cells?

A) antiprotozoan drugs

B) antihelminthic drugs

C) antifungal drugs

D) nucleotide analogs

E) semisynthetic penicillins


42) Mebendazole is supplied to treat cestode infections. It interferes with microtubule formation; therefore, it would NOT affect

A) bacteria.

B) fungi.

C) helminths.

D) person cells.

E) protozoa.


43) which of the following antibiotics causes misreading the mRNA?

A) aminoglycoside — changes shape of 30S units

B) chloramphenicol — inhibits peptide bonds in ~ 50S subunit

C) oxazolidinone — prevents formation the 70S ribosome

D) streptogamin — prevents release that peptide from 70S ribosome

E) tetracyclines — bind with 30S subunit


44) The antibiotic actinomycin D binding between adjacent G-C pairs, for this reason interfering with

A) transcription.

B) translation.

C) cellular respiration.

D) plasma membrane function.

E) peptide shortcut formation.


45) usage of antibiotics in pet feed leads to antibiotic-resistant bacteria because

A) bacteria from other pets replace those eliminated by the antibiotics.

B) the few surviving bacteria that are influenced by the antibiotics develop immunity to the antibiotics, which they happen on to their progeny.

C) the antibiotics cause brand-new mutations to take place in the surviving bacteria, which results in resistance come antibiotics.

D) the antibiotics kill prone bacteria, however the few that are naturally resistant live and reproduce, and their progeny repopulate the host animal.

E) the antibiotics persist in soil and water.


Answer: D


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1) an antibiotic that attacks the LPS layer would be intended to have a narrow spectrum that activity.


Answer: TRUE


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2) PABA serves together the compete inhibitor in the activity of sulfanilamides.


Answer: FALSE


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3) Undergrowth of fungi after antibiotic usage is generally referred to as a superinfection.


Answer: FALSE


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4) because of its target, rifamycins have the right to be effective over a vast spectrum.


Answer: TRUE


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5) Both trimethoprim and sulfamethoxazole inhibit reactions along the same metabolic pathway.


Answer: TRUE


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6) Penicillin and also streptomycin are commonly used in synergism due to the fact that they display the same setting of action.


Answer: FALSE


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7) just microbes produce antimicrobial peptides.

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Answer: FALSE


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8) Community-acquired MRSA is typically much more virulent than health care-associated MRSA.